### ‘Overlooked’ Vitamin Ubiquinol May Hold the Key to Fighting Fatigue and Increasing Energy, Researchers Say
A little-known nutritional compound called ubiquinol is emerging as a potential powerhouse in the fight against fatigue and could play a significant role in boosting energy, according to new research. Despite its promising health benefits, almost four in five people are unaware of this vital nutrient, highlighting a broad gap in public knowledge.
Over recent years, much attention has centred on the impact of nutrition and lifestyle choices on the development of chronic illnesses, such as cardiovascular and neurological diseases. Historically, the spotlight has fallen on the likes of carbohydrates, proteins, fibre, and more familiar vitamins and minerals. Now, however, experts are urging the public to sit up and take notice of ubiquinol, a compound providing important health benefits, especially as we age.
A study commissioned by Kaneka Ubiquinol, a manufacturer of this bioavailable form of Co-Enzyme Q10, found that only a quarter of those surveyed had heard of ubiquinol. Even fewer understood the differences between ubiquinol and other related nutrients, such as ubiquinone (the oxidised form of CoQ10), or knew if these nutrients affected health. Knowledge about which form of coenzyme Q10 is best absorbed by the body was also low, with just over a quarter recognising ubiquinol’s superior bioavailability.
The body naturally produces CoQ10, but this ability declines with age. Moreover, certain medications—including cholesterol-lowering statins—and environmental factors may further reduce natural levels of CoQ10 and ubiquinol in the body. For older adults especially, incorporating ubiquinol-rich foods or supplements into their diets could prove particularly beneficial, according to experts.
Dr Emma Derbyshire, a public health nutritionist and member of the Kaneka Ubiquinol expert panel, describes ubiquinol as “a vitamin-like substance powering the cells of the body and playing a major role in reducing oxidative stress”. She compared ubiquinol’s function within the cell to that of petrol in a car, being vital for cellular energy production and organ function. She also highlighted that ubiquinol is the active and more easily absorbed form of CoQ10, making it more effective for use by human cells compared to its counterpart, ubiquinone.
Emerging evidence suggests that ubiquinol could help mitigate several health issues. High concentrations of ubiquinol are found in the heart, supporting efficient energy production and acting as a robust antioxidant. A recent review led by Dr Derbyshire, published in a journal on gynaecology and women’s health, found that ubiquinol was linked to improvements in egg quality, markers of sperm health, and hormone balance—showing promise even in addressing challenges such as polycystic ovary syndrome (PCOS).
The compound’s antioxidant properties may also defend cells from ‘free radicals’, which are unstable molecules generated by environmental factors like tobacco smoke and air pollutants. When the body’s defences against these molecules are overwhelmed, damage to cells occurs, a phenomenon known as oxidative stress. Ubiquinol’s unique ability to neutralise free radicals can help restore balance, potentially offsetting a host of health concerns linked to oxidative damage.
Fatigue is another area garnering attention in research on ubiquinol supplementation. The nutrient helps manufacture adenosine triphosphate (ATP), the energy molecule produced in a cell’s mitochondria—sometimes described as the ‘power stations’ inside our cells. Some small studies suggest that daily intake of ubiquinol could significantly reduce feelings of tiredness—particularly the sort related to physical exertion or chronic low energy—by supporting energy-requiring processes in the body.
Dietary sources of ubiquinol include oily fish, poultry, citrus fruits, and a variety of nuts and seeds, but achieving effective amounts through diet alone may be challenging. Supplementation is available, but experts recommend speaking with a GP before introducing any new supplements, especially if taking prescription medications, as interactions can occur.
Dr Derbyshire believes ubiquinol will become a bigger focus in future discussions about healthy ageing and active lifestyles. Although scientific understanding is developing, initial findings are promising, particularly for those seeking to enhance energy and overall vitality. However, as always, individual medical advice should be sought before starting any new health regimen.
As the nation becomes more health-conscious, expanding awareness about less familiar nutrients like ubiquinol could prove crucial in enabling more people to take charge of their wellbeing. In the meantime, experts advise a balanced approach—anchored in whole foods, regular physical activity, and professional medical guidance—as the best foundation for long-term sustainability and health.